What changed
Added the source-verified Claim Check to the structured claim/source/change registry.
Source record · FDA evidence review and human biomarker study · reviewed July 18, 2026
Endogenous biomarker research is not proof that MOTS-c injections improve weight or performance.
The circulating claim“MOTS-c injections are proven to improve weight loss, energy, and exercise performance.”
What the source record says
Human exercise studies measured the body's own MOTS-c; they did not administer MOTS-c as a treatment. FDA says it did not identify studies administering MOTS-c to humans or human exposure data through any route.
Why the claim misleads
Measuring a naturally occurring peptide during exercise is being treated as evidence for giving a manufactured peptide as a treatment.
Correction
Endogenous biomarker research is not proof that MOTS-c injections improve weight or performance.
Primary sources
FDA MOTS-c briefing document, 2026Open source ↗von Walden et al., 2021 — endogenous MOTS-c and exerciseOpen source ↗MOTS-c library entryOpen source ↗What would change our answer
A well-controlled human study tied to the exact product, population, route, and claimed outcome could change the answer. Mechanism, anecdotes, or a different product cannot substitute for that evidence.
Version history · 1 entry
- v1 · 2026-07-18Initial structured record created from the reviewed Claim Check.Source ↗
Boundary: This check evaluates a public claim. It does not assess an individual product or person and is not treatment, dosing, sourcing, or legal advice.